IMMORTAL Cell Sciences
Science of Fat Loss
Knowledge is Power
Immortal's B5 FAT BURNING TECHNOLOGY products raise awareness of Dr. Leung's breakthrough Vitamin B5 discoveries (i.e., that Vitamin B5 increases coenzyme A) . Large amounts of vitamin B5 help create more ATP (more energy supports a higher metabolism) while reducing hunger. Oh, and by the way, Leung tells us that ketone bodies (i.e., ketosis) results from inefficient fat burning. With high-dose vitamin B5, more Coenzyme-A leads to more efficient fat burning - without ketosis.
Combining Leung's B5 discovery with Dr. Richard J. Johnson's discovery that the sugar fructose via a uric acid pathway turns on the Fat Switch, we now have the understanding how to reduce fat, and keep it off.
Pantothenic Acid as a Weight-Reducing Agent: Fasting Without Hunger, Weakness and Ketosis
L. H. LEUNG
Department of General Surgery, Hong Kong Central Hospital, 1 Lower Albert Road, Hong Kong
Medical Hypotheses (1995) 44, 403-405
During a year long study of 100 subjects, Leung' tested his Vitamin B5/CoA theory. Subjects lost 1.2 Kg per week on a 1000 calorie diet, without ketosis. The only reported "side effect" was the feeling of well-being.
Abstract -- With the conventional method of fasting or aggressive dieting to reduce excess body fat, hunger, weakness, ketogenesis and ketosis are the sequential events that follow. It is not fully understood why, under conditions of negative calorie balance where complete energy release from storage fat is critical, ketosis should arise with a concomitant wastage of energy. Here, I wish to propose a theory that relates the formation of ketone bodies under such conditions to a deficiency in dietary pantothenic acid. Supplementation of this vitamin would facilitate complete catabolism of fatty acids and thus the formation of ketone bodies could be circumvented. As a result, a sufficient amount of energy would be released from storage fat to relieve dieters of the sensation of hunger and weakness which otherwise would be difficult to endure. Hence, using this method for weight reduction together with a careful observation of calorie intake, I have great success in treating overweight-to-obese patients to lose weight.
A Stone that Kills two Birds: How Pantothenic Acid Unveils the Mysteries of Acne Vulgaris and Obesity . Department of Surgery. Hong Kong Central Hospital. Hong Kong Lit-Hung Leung. M.D. Journal of Orthomolecular Medicine Vol. 12, No. 2, 1997) .
Abstract Acne vulgaris is the most common disease of the skin. Obesity is arguably the commonest of a clinical entities in the affluent society. The pathogenesis of these disorders is far from clear cut and they appear to have little in common. In the present paper it is hypothesized that the pathogenesis of both acne vulgaris and obesity is largely due to a relative deficiency of the same agent, pantothenic acid, a vitamin that is hitherto quite unknown to cause any deficiency syndromes in man. Furthermore, the evidence suggests that surprisingly large doses of pantothenic acid are required to overcome deficiency states as illustrated in the treatment of acne vulgaris and weight reduction.
J Biol Chem. 2019 Mar 15;294(11):4272-4281. doi: 10.1074/jbc.RA118.006158. Epub 2019 Jan 16.
Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic fat accumulation. Moreover, fructose metabolism yields uric acid, which is highly associated with NAFLD. Here, using biochemical assays, reporter gene expression, and confocal fluorescence microscopy, we investigated whether uric acid regulates aldose reductase, a key enzyme in the polyol pathway. We evaluated whether soluble uric acid regulates aldose reductase expression both in cultured hepatocytes (HepG2 cells) and in the liver of hyperuricemic rats and whether this stimulation is associated with endogenous fructose production and fat accumulation.
J Intern Med. 2019 Oct 17. doi: 10.1111/joim.12993. [Epub ahead of print]
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts.
Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse. Here, we describe a survival pathway used by many species as a means for providing adequate fuel and water, while also providing protection from a decrease in oxygen availability. Fructose, whether supplied in the diet (primarily fruits and honey), or endogenously (via activation of the polyol pathway), preferentially shifts the organism towards the storing of fuel (fat, glycogen) that can be used to provide energy and water at a later date. Fructose causes sodium retention and raises blood pressure and likely helped survival in the setting of dehydration or salt deprivation. By shifting energy production from the mitochondria to glycolysis, fructose reduced oxygen demands to aid survival in situations where oxygen availability is low. The actions of fructose are driven in part by vasopressin and the generation of uric acid. Twice in history, mutations occurred during periods of mass extinction that enhanced the activity of fructose to generate fat, with the first being a mutation in vitamin C metabolism during the Cretaceous-Paleogene extinction (65 million years ago) and the second being a mutation in uricase that occurred during the Middle Miocene disruption (12-14 million years ago). Today, the excessive intake of fructose due to the availability of refined sugar and high-fructose corn syrup is driving 'burden of life style' diseases, including obesity, diabetes and high blood pressure.
Nothing Beats Knowledge Backed by Science
The essence of a successful effortless, sustainable fat loss program:
#1 Turn off the Fat Switch: Avoid eating the sugar Fructose (and don't restrict Salt). Table sugar is half fructose. Restricting sugars is the reason why a low-carb diet works for rapid weight loss. Unfortunately, the lack of glucose is not healthy and cannot be sustained because our bodies require glucose. (Eating fruit is probably the ideal means for obtaining the best glucose (along with the least problematic fructose).
#2 Eat mainly whole foods, preferably organic (minus any hormones or pesticides). This healthy choice reduces the intake of fructose. Again, a plant-based diet of fruits and vegetables would be ideal.
#3 Consider exercise. Putting the body to work should shorten the time to become fat adapted (converting the body to burn fat, instead of glucose.)
#4 Consider intermittent fasting. To speed fat adaption, correct insulin resistance, and according to Dr. Fung, to lower the body weight set point. (The issue fasting solves is the excess fructose (from ordinary sugar) in almost everything we like to eat. B5 can help with reducing hunger and weakness during fasting.)
IMMORTALS contribution -- Products that make it easy to maintain a higher metabolism, without hunger, or weakness, while intermittent fasting.
#3 Supplement at least 10 grams of Vitamin B5 (pantothenic Acid) daily. Divide into 4 equal doses, and take between meals. If there is ketosis, increase the dosage, to as much as 20,000 mg of vitamin B5 daily.